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A 16th century Escherichia coli draft genome associated with an opportunistic bile infection

It is the first ancient genome of Escherichia coli and was also responsible for creating several gallstones.

Evolution of immune genes is associated with the Black Death

Genes that protected our ancestors from Black Death make us more susceptible to autoimmune disorders today

Targeted enrichment of ancient pathogens yielding the pPCP1 plasmid of Yersinia pestis from victims of the Black Death

Here we report the entire full pPCP1 virulence-associated plasmid of Yersinia pestis as high coverage, the longest contingous genomic sequence of an ancient ...

Quantitative Assessment of the Sensitivity of Various Commercial Reverse Transcriptases Based on Armored HIV RNA

Here we report a systematic comparison of 11 commercially available reverse transciptases for cDNA synthesis. Our analysis reveals significant variation in the ...

A molecular analysis of ground sloth diet through the last glaciation

We extracted DNA from five coprolites dated between 11,000 years ago and 28,500 years ago all excavated in Gypsum Cave. All coprolites contained DNA ...

Bacillus DNA in Fossil Bees: an Ancient Symbiosis?

We have isolated DNA from the abdominal tissue of four extinct stingless bees in Dominican amber, and conducted PCR amplification targetting the 16S rRNA gene. ...

Ancient whole genome enrichment using baits built from modern DNA

Study validating the use of reference-free bait synthesis for whole-genome enrichment.

Estimation of gene insertion/deletion rates with missing data

Lateral gene transfer is an important mechanism for evolution among bacteria. Here, genome-wide gene insertion and deletion rates are modelled in a maximum ...

North American Mammoth Diversity and Interbreeding

Here we report the sequencing of 67 new mammoths including non-Woolly specimens representing Columbian (Mammuthus columbi), Jeffersonian (Mammuthus ...

The Justinianic Plague: An inconsequential pandemic?

New research suggests that reports of death in the wake of the Justinian Plague have been greatly exaggerated.